Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. doi: 10.1016/j.bmcl.2006.05.019. Epub 2006 May 24.

Abstract

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

MeSH terms

  • Drug Design
  • Enzyme Inhibitors / pharmacology*
  • MAP Kinase Kinase 1 / antagonists & inhibitors*
  • Thiazoles / pharmacology*

Substances

  • Enzyme Inhibitors
  • Thiazoles
  • MAP Kinase Kinase 1